Overview

Through an interdisciplinary collaboration, a team of researchers from CS and Biology in UNC-Charlotte and Carolina Medical Center have analyzed the behavior of cells (red, white and natural killer T) in liver with respect to the pathological conditions of trauma and cancer in in vivo images through development of automated cell motion analysis algorithsm.

Team Members

• UNC Charlotte (Computer Science): Min C. Shin, Ph.D, Steve Schmugge, Jerrod Kraftchick, Rich Nguyen
• UNC Charlotte (Biology): Mark Clemens, Ph.D.
• Carolina Medical Center: Toan Huynh, M.D., Steve Keller

Supports

• Automated analysis of NKT cell sentry pattern in liver with metastatic tumor, National Institute of Health, 1/2007 - 1/2009, $352,500, (co-PI. PI Mark Clemens)
• An efficient, robust, and sensitive analysis of the liver microcirculation after trauma and sepsis, Carolinas HealthCare Systems, 1/2007 – 12/2007, $18,000, (co-PI; PI Toan Huynh)
• Modulation of Liver Microcirculation by Leukocyte, Platelet and the Endothelium after Sepsis, Carolinas HealthCare Systems, 6/1/07-9/1/07 for $3,200 (co-PI.  PI: Toan Huynh)

Publications

1. Walid S. Kamoun, Stephen J. Schmugge, Jerrod Kraftchick, Mark. G. Clemens, Min C. Shin, "Liver Microcirculation Analysis by Red Blood Cell Motion Modeling in Intravital Microscopy Images", Accepted to appear in IEEE Transactions on Biomedical Engineering (web)
2. Walid S. Kamoun, Min C. Shin, Steve Keller, Amel Karaa, Toan Huynh, Mark G. Clemens, "Induction of biphasic changes in perfusion heterogeneity of rat liver following sequential stress in vivo", Shock, 2005 Oct, 24(4): 324-331 (Impact Factor: 3.122)
3. W. Kamoun, Min C. Shin, Amel Karaa, and M. Clemens, "Quantification of Hepatic Microcirculation Heterogeneity of Perfusion: Effects of Endothelin-1" Microvascular Research, Volume 69, Issue 3 , May 2005, Pages 180-186 (Impact Factor: 2.359)
4. S. Schmugge, W. Kamoun, J. Villalobos, M. Clemens, and M. Shin, "Segmentation of Vasculature for Intravital Microscopy using Bridging Vessel Snake." Proceedings of the IEEE International Symposium on Biomedical Imaging: From Nano to Macro 2006 (308/549)
5. S. Babu, P.-C. Liao, M. C. Shin, and L. V. Tsap, "Recovery and Visualization of 3D Structure of Chromosomes," EURASIP Journal on Applied Signal Processing 2006
6. S. Babu, P.-C. Liao, M. C. Shin, and L. V. Tsap, "Towards Recovery of 3D Chromosome Structure," IEEE Workshop on Articulated and Nonrigid Motion (held in conjuction with CVPR 2004), Washington, D.C., June 2004.